Anti-inflammatory Herb-Scute

Scute (Scutellaria Baicalensis) is one of the core ingredients of FlameEz™. It is also one of the most respected and utilized herbs in traditional Chinese medicine. Scute was used safely for centuries in traditional medicine to treat allergies, infections, inflammation, cancer, and headaches. Its anti-inflammatory, antibacterial, antifungal and antiviral properties have been utilized in contemporary medicine. Recent research also reveals that Scute has anti-cancer and anti-allergy effects and benefits for treating diabetes and high blood pressure.

The root of Scute is a rich source of over 35 flavonoids. The main active ingredients modulating inflammation include baicalein, baicalin, and wogonin. They are potent free radical scavengers and xanthine oxidase inhibitors.

Scute has been the subject of intensive study. Based on published scientific and clinical research, Scute:

• Inhibits proinflammatory mediators such as cyclooxygenase-2, leukotriene B4, IL-1 beta, 12-lipoxygenase and prostaglandin E2*
• Reduces production of nitric oxide and free radicals*
• Reduces cancer cell growth and induces apoptosis of cancer cells*
• Protects DNA from undergoing cancerous mutations*
• Stimulates recombination and repair of damaged DNA*
• Has antiviral/anti-HIV effects*
• Inhibits type I and II hyper-sensitivity reactions in asthma and allergies*
• Prevents the buildup of amyloid beta peptides in the brain and protects nerve cells from damage*
• Relieves stomach damage and nausea caused by anti-cancer drugs and antiviral drugs used to treat AIDS*

*These statements have not been evaluated by the Food and Drug Administration.

Reference (for abstracts and additional references, click here):

1. Han J. et al. Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. 848(2):355-62, 2007
2. Leung HW. et al. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Food & Chemical Toxicology. 45(3):403-11, 2007
3. Huang WH.et al. Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. Bioscience, Biotechnology & Biochemistry. 70(10):2371-80, 2006
4. Zhang Y. et al. Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury. Journal of Ethnopharmacology. 108(3):355-60, 2006
5. Zhao Y. et al. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. European Journal of Pharmacology. 536(1-2):192-9, 2006
6. Wang JY. et al. Effects of Scutellaria baicalensis Georgi on macrophage-hepatocyte interaction through cytokines related to growth control of murine hepatocytes. Experimental Biology & Medicine. 231(4):444-55, 2006
7. Woo KJ. et al. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. Immunobiology. 211(5):359-68, 2006
8. Cho J. Lee HK. Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Biological & Pharmaceutical Bulletin. 27(10):1561-4, 2004
9. Huang Y. et al. Biological properties of baicalein in cardiovascular system. Current Drug Targets - Cardiovascular & Haematological Disorders. 5(2):177-84, 2005
10. Tang W. et al. Flavonoids from Radix Scutellariae as potential stroke therapeutic agents by targeting the second postsynaptic density 95 (PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95. Phytomedicine. 11(4):277-84, 2004.
11. Heo HJ. et al. Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. Journal of Agricultural & Food Chemistry. 52(13):4128-32, 2004
12. Zhang DY. et al. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Research. 63(14):4037-43, 2003
13. Chi YS. et al. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochemical Pharmacology. 66(7):1271-8, 2003
14. Kang BY. et al. Involvement of nuclear factor-kappaB in the inhibition of interleukin-12 production from mouse macrophages by baicalein, a flavonoid in Scutellaria baicalensis. Planta Medica. 69(8):687-91, 2003
15. Ye F. et al. Anticancer activity of Scutellaria baicalensis and its potential mechanism. Journal of Alternative & Complementary Medicine. 8(5):567-72, 2002

Herbal Information

Astragalus              
Boswellia                  
Chuanxiong         
Coptis
Eucommia               
Ginkgo Biloba           
Lycium               
Milk Thistle
Saw Palmetto          
Scute                      
Turmeric