Anti-inflammatory Herb-Turmeric

Turmeric (Curcuma longa) is one of the core ingredients of FlameEz™. The use of Turmeric for treatment of different inflammatory diseases has been described in Ayurvedic medicine and in traditional Chinese medicine for thousands of years. The active component of Turmeric responsible for anti-inflammatory activity is curcumin, which was identified two centuries ago. Since then, there have been over 1,800 citations in Medline relating to the biologic effects of curcumin. Modern science has revealed that curcumin mediates its effects by modulation of several important molecular targets, including transcription factors (e.g., NF-kappa B, AP-1, Egr-1, beta-catenin, and PPAR-gamma), enzymes (e.g., COX2, 5-LOX, iNOS, and hemeoxygenase-1), cellcycle proteins (e.g., cyclin D1 and p21), cytokines (e.g., TNF, IL-1, IL-6, and chemokines), receptors (e.g., EGFR and HER2), and cell surface adhesion molecules. It is widely used in traditional medicine to treat biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis.

Based on published scientific and clinical research, Turmeric and its active ingredient curcumin:

• Reduce blood cholesterol*
• Prevent low-density lipoprotein oxidation*
• Inhibit platelet aggregation and thrombosis*
• Inhibit HIV replication*
• Enhance wound healing*
• Protect the liver from injury*
• Reduce cancer cell growth*
• Suppress diabetes, rheumatoid arthritis, multiple sclerosis, and Alzheimer’s disease*

*These statements have not been evaluated by the Food and Drug Administration.

Reference (for abstracts and additional references, click here):

1. Hsu CH. Cheng AL. Clinical studies with curcumin. Advances in Experimental Medicine & Biology. 595:471-80, 2007.
2. Park C.et al. Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. International Journal of Molecular Medicine. 20(3):365-72, 2007
3. Nonn L. et al. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis. 28(6):1188-96, 2007
4. Bright JJ. Curcumin and autoimmune disease. [Review] [166 refs] Advances in Experimental Medicine & Biology. 595:425-51, 2007.
5. Garcia-Alloza M. et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102(4):1095-104, 2007
6. Mrudula T. et al. Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochemical & Biophysical Research Communications. 361(2):528-32, 2007
7. Reinke AA. Gestwicki JE. Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility. Chemical Biology & Drug Design. 70(3):206-15, 2007
8. Khanna D. et al. Natural products as a gold mine for arthritis treatment. [Review] [68 refs] Current Opinion in Pharmacology. 7(3):344-51, 2007
9. Xu Y. et al. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Research. 1162:9-18, 2007
10. Narlawar R. et al. Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism. [Review] [41 refs] Neurodegenerative Diseases. 4(2-3):88-93, 2007.
11. Cao J. et al. Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells. Free Radical Biology & Medicine. 43(6):968-75, 2007Thangapazham RL. Sharma A. Maheshwari RK. Beneficial role of curcumin in skin diseases. [Review] [78 refs] Advances in Experimental Medicine & Biology. 595:343-57, 2007.
12. Fan C. et al. Effect of curcumin on the expression of LDL receptor in mouse macrophages. Journal of Ethnopharmacology. 105(1-2):251-4, 2006
13. Chen J. et al. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis. 11(6):943-53, 2006
14. Xia Q. et al. Molecular genetic and chemical assessment of Rhizoma Curcumae in China. Journal of Agricultural & Food Chemistry. 53(15):6019-26, 2005

Herbal Information

Astragalus              
Boswellia                  
Chuanxiong         
Coptis
Eucommia               
Ginkgo Biloba           
Lycium               
Milk Thistle
Saw Palmetto          
Scute                      
Turmeric